local intelligence

can it run

Can the AMD Instinct MI355X 288GB run qwen3 235B-A22B MoE?

FULL

142.7 GB needed of 288 GB usable — headroom for context

288GB · CDNA4 · model file 142GB · 235B-A22B MoE

~170–270 tok/s (active-expert estimate)

computed roofline: 8000 GB/s × 0.28–0.45 efficiency window / 13.3GB (Q4_K_M) — bands, never points.

MoE: file is 142GB (that decides fit) but only ~22B of experts activate per token (~13.3GB streamed) — band below is the active-expert estimate, optimistic; community MoE rows run several× the naive bandwidth math

Run qwen3 235B-A22B MoE on instead

ASUS ExpertCenter Pro ET900N G3 (GB300) — cheapest catalog machine that runs qwen3 235B-A22B MoE fully ($60000)

NVIDIA DGX Station (GB300) — upgrade path machine

every model the AMD Instinct MI355X 288GB can run — full list

explore the full catalog90 machines indexed · live prices · what each one can run
2026-09-24 · ← all models on the AMD Instinct MI355X 288GB · fit = weights + 4k KV vs usable memory